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compatibility of irinotecan-loaded dc bead with different volumes and types of non-ionic contrast media

by:Top-In     2020-08-07
Elitikang-
The loaded microsphere is used for simultaneous embolism and chemotherapy of liver metastasis in colorectal cancer.
The purpose of this study is to evaluate the compatibility of the recently launched DC BeadM1 (
Bead size 70-150 m)
Loaded after a non-mixture of different types and volumes
Use ion contrast agent within maximum 24 hours and store at room temperature.
Methods a Test suspension agent was prepared by 100mg elitikang loading 2 ml DC be1 within 2 km/h h.
Determination of loading efficiency by reverse high-pressure liquid chromatography to measure the concentration of elitikang in excessive solution (RP-HPLC)
Analysis with UV detection.
Compatibility of elitikang
By mixing the 2 ml loaded bead paste with up to four different volumes of bead paste, DC be1 loaded with different types and volumes of contrast media was studied (
5, 10, 20, 30 ml)
Seven different contrast media
Samples were extracted after 30 min, 1, 2, 4, 8 and 24 h.
During the observation period, the mixture stores light protection at room temperature.
Use RP-to determine the concentration of elitikang eluted in three samplesHPLC assay.
Results of irtikang load bead mixing with non-load bead
The ion contrast agent reduces the load efficiency of elitikang between the lowest 2.
5%, up to 17% during the 24-hour observation period.
The rate and amount of eluding from beads varies depending on the type and volume of the contrast medium added.
However, after the first rapid release of 8 Thanh, no further washout or degradation was observed.
Conclusion due to the rapid and extensive release of elitikang, it is not recommended to prepare the mixture of elitikang
In advance, DC BeadM1 with contrast media is loaded in the centralized cell toxicity preparation unit.
Before delivery, the radiologist should mix in as little amount as possible.
Elitikang-
The loaded microsphere is used for simultaneous embolism and chemotherapy of liver metastasis in colorectal cancer.
The purpose of this study is to evaluate the compatibility of the recently launched DC BeadM1 (
Bead size 70-150 m)
Loaded after a non-mixture of different types and volumes
Use ion contrast agent within maximum 24 hours and store at room temperature.
Methods a Test suspension agent was prepared by loading 2 ml DC BeadM1 with 100mg irtikang within 2 km/h h.
Determination of loading efficiency by reverse high-pressure liquid chromatography to measure the concentration of elitikang in excessive solution (RP-HPLC)
Analysis with UV detection.
Compatibility of elitikang
By mixing the 2 ml loaded bead paste with up to four different volumes of bead paste, DC be1 loaded with different types and volumes of contrast media was studied (
5, 10, 20, 30 ml)
Seven different contrast media
Samples were extracted after 30 min, 1, 2, 4, 8 and 24 h.
During the observation period, the mixture stores light protection at room temperature.
Use RP-to determine the concentration of elitikang eluted in three samplesHPLC assay.
Results of irtikang load bead mixing with non-load bead
The ion contrast agent reduces the load efficiency of elitikang between the lowest 2.
5%, up to 17% during the 24-hour observation period.
The rate and amount of eluding from beads varies depending on the type and volume of the contrast medium added.
However, after the first rapid release of 8 Thanh, no further washout or degradation was observed.
Conclusion due to the rapid and extensive release of elitikang, it is not recommended to prepare the mixture of elitikang
In advance, DC BeadM1 with contrast media is loaded in the centralized cell toxicity preparation unit.
Before delivery, the radiologist should mix in as little amount as possible.
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