bruker corporation (brkr)
Annual reports submitted under sections 13 or 15 (d)
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30833 Brook Company (
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40 Manning Road, Marika (
Main executive office address)01821(Zip Code)
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3660 securities registered under section 12 (b)
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ContentsBRUKER Company Annual Report on table 10
Contentspageitemitem 1 business 3 item 1 factork factors17item 1 bunresolved employee comment 34 item 2 property 34 item 3 legal action s35item 4 Registrant security disclosure related shareholder matters and issuer purchase equity securities 37 items 6 Selected finances data 39 items 7 Management Discussion and Analysis of financial position and results of operations 41 items 7 quantitative and qualitative disclosure of market risk disclosure124Item9AControls and procure124item9bother Information124PartIIIItem10Directors, executive officers and company managers of certain beneficial owners and management and related shareholders 12 item 11 executive compensation 12 item 12 item 12 ownership of securities certain relationships and related transactions and director independence 126 item 14 principal accountant fees
K. summary contained in the annual report on Form10
K, which is not a statement of historical facts, can be considered forward-
Looking forward to the statements contained in Section 21e of the Securities Exchange Act of 1934 and Section 27a of the Securities Act of 1933.
Without limiting the foregoing, \"Believe\", \"expect\", \"plan\", \"expect\", \"seek\", \"possible\", \"will\", \"intention\", \"estimate\", \"should\" and similar the expression is designed to identify forward-
Look at the report. Any forward-
The forward-looking statements contained here are based on current expectations, but there are some risks and uncertainties.
Forward-looking statements include, but are not limited to, statements regarding our intentions with respect to intellectual property rights, the impact of government contracts and government regulation, our working capital requirements and sufficient cash, seasonality of our business, adequacy of facilities, employee relations, impact of legal proceedings, changes in tax and accounting rules and the impact of changes in the law, the tax rate we expect, our expectations for cash dividends, expenditures and capital expenditures, the impact of changes in foreign exchange rates and commodity prices, and our expectations for content income.
Factors that may lead to significant differences between actual future results and current expectations include, but are not limited, adverse changes in the economic and political conditions of the country in which we operate, integration of businesses we have acquired or may acquire in the future, risks and uncertainties associated with our restructuring and costs
Control plans, changing technologies, product development and market acceptance of our products, cost and pricing of our products, manufacturing and outsourcing, competition, capital to partners, major suppliers and third-party distributors spending and government funding policies, changes in government regulations, intellectual property, litigation, risk of foreign exchange fluctuations, our ability to repay debts, the ability to fund our expected cash needs, the impact of centralized ownership of our common shares, loss of key personnel, payment of future dividends, climate change and other factors.
Many of these factors are described in more detail in this annual report on Form10K under Item1A.
\"Risk Factors\" and other documents that we may submit to the Securities and Exchange Commission from time to time.
Although we may choose to update forward
Looking forward to future statements, we expressly deny any obligation to do so, and even if our estimates change, readers should not rely on these forward-looking statements
From any date from the date of submission of this report, the statement represents our point of view.
\"We\", \"management\" or \"Company\" refer to the Brook company, which in some cases is its subsidiaries, as well as all former entities.
Our main executive office is located at 40 Manning Road, Billerica, MA 01821, and our telephone number is (978)663-3660.
Information about Brook. bruker. com.
The information on our website is not incorporated into this report by reference, nor is it part of this report.
All trademarks, trade names or copyrights referred to in this report are the property of their respective owners.
2 ContentsPART IITEM 1 business table we are a developer, manufacturer and distributor
Performance science instruments and analytical diagnostic solutions enable our customers to explore life and materials at the micro, molecular and cellular levels.
Many of our products are used to detect, measure and visualize the structural features of samples of chemical, biological and industrial materials.
Our products meet life science research, pharmacy, biotechnology, application market, cell biology, clinical research, microbiology, in-
In vitro diagnosis, nanotechnology and scientific research of materials.
Our technical platform includes magnetic resonance technology, mass spectrometry technology, gas phase and liquid phase chromatography triple four-bar mass spectrometry technology, X-
Optical emission spectroscopy, atomic force microscopy, stylus and optical metrology techniques, fluorescent optical microscopy, and infrared and Raman molecular spectroscopy techniques.
We also develop, manufacture and distribute a range of on-site analytical systems for chemical, biological, radiological, nuclear and explosive or CBRNE detection.
Our infectious disease portfolio includes DNA test strips and fluorescence.
PCR-based reaction (PCR)
Technology applied to specific infectious diseases.
We also develop, manufacture and sell high-and low-temperature conductive materials and devices mainly based on metal low-temperature magnets.
Our company is headquartered in Bianca, Massachusetts.
We have major technology and manufacturing centers in Europe and North America and sales offices around the world.
In February 1991, we set up Brook federal systems in Massachusetts.
We re-registered as Bruker DaltonicsInc in Delaware in February 2000.
We merged with Bruker AXSInc in July 2003.
We were the surviving company in that merger.
In this merger, we renamed Brooke Bioscience and established two operating subsidiaries, Brooke Daltonics and Brooke AXS.
We acquired Bruker OpticsInc in July 2006.
In February 2008, we acquired the Bruker BioSpin Corporation group and changed our name to Bruker Corporation.
We have two market segments that can be reported, Brooke science instruments (BSI)
During the year ended December 31, 2018, andBruker Energy & Supercon Technologies accounted for about 90% of our revenue (BEST)
This represents the rest of our income.
In BSI, we are divided into three operations: Brook bio-rotation group, Brook CALID group and Brook Nano group.
For the purposes of financial reporting, Bruker BioSpin, Bruker CALID and Bruker Nano operations are aggregated into departments where BSI can report, because each department has a similar approach to economic features, distribution and regulatory environments.
Brusgmentbruker BioSpin Group Bruker BioSpin Group includes Bruker magnetic resonance, applied industrial and clinical, clinical imaging and services, and life cycle support departments and design, manufacturing and selling support life sciences tools based on magnetic resonance technology.
Magnetic resonance is a natural phenomenon that occurs when the molecules placed in the magnetic field emit characteristic RF.
Characteristic radio frequency is a characteristic of a specific molecule, which provides 3 tables of accurate chemical and structural information.
According to the expected application, we sell the NMR system or EPR system to the customer (
Each definition is as follows).
BrukerBioSpin also manufactures and sells single mode and multi mode systems using MRI, PET, SPECT, CT and MPI Technologies (
Each definition is as follows).
Bruker BioSpin\'s products have special applications in the fields of structural proteomics, drug discovery, pharmaceutical and biotechnology research and production, and food and material science, provides customers with the dynamics and functions of specific molecules (such as proteins) that determine the structure, as well as the representation and determination of the composition of the mixture.
The main clients of Bruker BioSpin are academic and government research institutions.
Other clients include pharmaceutical and biotechnology companies;
Chemical, food and beverage, clinical and polymer companies, and non-profit laboratories.
Over the course of 2018, we launched a number of new products and technologies, including new probe technologies and our next generation honey screening device.
We also installed a high. field 9.
Nuclear magnetic resonance of Teslasmall animals (Described below)
Integrated Systemline PET (Described below).
During 2018, we received a 51% interest in Mestrelab Research. L.
This will further expand our software technology.
The instruments of BrukerBioSpin Group are based on the following technical platforms: MRI;
Electron shunmagnetic resonance;
Magnetic resonance imaging;
Magnetic particle imaging;
Electron Emission Tomography;
Single Photon Emission Tomography;
Nmr is a qualitative and quantitative analytical technique for determining the molecular structure and purity of samples.
The molecules are placed in a magnetic field, sending out RF signals recorded by sensitive detectors.
The analysis software helps to determine the molecular structure of the sample.
NMR technology is used in academia, pharmaceutical, biotechnology, food and beverage and clinical companies, as well as other industrial users in life sciences and materials science research.
The Epr is the process of absorbing microwave radiation by shunmagnetic ions or molecules, with at least one unpaired electron rotating under a static magnetic field.
EPR can detect unpaired electrons without ambiguity, while other techniques can only provide indirect evidence of their existence.
In addition, EPR can identify the detected shunmagnetic species that provide information on molecular structures near unpaired electrons and gain insight into dynamic processes such as molecular movement or fluidity.
Our EPR instruments are widely used in advanced materials research, material analysis and quality control.
MRIis is the process of creating an image through manipulation of hydrogen atoms in a magnetic field.
In the presence of an external magnetic field, the atom will be aligned or aligned with the external magnetic field.
The application of radio frequency can cause atoms to jump between high energy and low energy.
Magnetic resonance and magnetic resonance imaging include many methods, including diffusion-
Weighted, molecular imaging and contrastenhance.
MRI provides high-resolution morphological information, as well as functional, metabolic, or molecular information.
Customers use our 4-table content system in drug research including metabolic omics to study some diseases, including diabetes, neurology, oncology, and cardiovascular diseases.
MPIis is the process of creating images from magnetic particles to the animal\'s body.
Magnetic particles are manipulated in a combination that shows the oscillating magnetic field in the no-magnetic field area.
The response of the particles allows real-time 3D data collection of the entire body of the animal, showing contrast agents distributed in the body and flowing through the body.
This imaging method is used to detect cardiovascular diseases.
PETis is the process of creating images from positrons after applying radionuclides to the animal\'s body.
The destruction of positrons produces two photons, with an angle of 180 ° between them, separating these photons from other sources.
PET tracerenriches are rich in certain areas of interest in the body and obtain molecular information from animals.
This is widely used in oncology, inflammation, neurology and cardiovascular diseases, as well as metabolic diseases, drug discovery and bone diseases.
Spectuse contains a contrast agent for radionuclides that directly emit single photons.
Contrast agents are rich in certain parts of the animal\'s body and produce images of the distribution of radionuclides in the body.
In animal in vivo research, the most important thing is that in oncology, neurology and cardiovascular diseases, tomography has a wide range of applications.
Technology based on X
Light used to generate a complete 3D data set.
The most important application is organization sample analysis or non-
Imaging of living animals.
CT provides the highest spatial resolution of all pre-clinical imaging patterns, especially to help generate morphological information about the object or animal being investigated.
CT is being used in a wide range of pre-clinical studies such as bone-
Orthopedics, cardiovascular, lung, tumor, metabolism, etc.
Bruker CALID Group is composed of Bruker Daltonics, Bruker Detection and Bruker optics.
The Bruker Daltonics Division primarily designs, manufactures and distributes life sciences mass spectrometry or MS instruments that can be integrated and used with other sample preparation or chromatography instruments.
These products are used in research, pharmaceutical and biotechnology development, and in clinical diagnostic environments.
Mass spectrometer is a precision device for measuring molecular mass or weight, which can provide accurate information about the identity, quantity and primary structure of molecules.
Mass spectrometry-based solutions typically combine advanced mass spectrometry instruments, automated sampling and sample preparation robots, kits, and other disposable products for testing or analysis, as well as Bioinformatics software.
We offer mass spectrometry systems and integrated solutions for applications in multiple existing and emerging life sciences markets as well as in the chemical and application markets, including Expression proteomics, clinical proteomics, molecular diagnostic studies and molecular and Systemic Biology of metabolic and peptide biomarkers, as well as basic molecular medical research and clinical microbiology (
In vitro diagnosis (IVD)
Used only in certain countries and in certain configurations).
TheBruker testing department provides various systems based on mass spectrometry, ion migration spectrum, infrared spectrum and Radioactive/nuclear detectors for CBRNE detection in emergency response, homeland security and defense applications.
TheBruker optical division produces and sells research, analysis and process analysis instruments and solutions based on infrared and Raman molecular spectroscopy technologies.
These products are used in industry, government and academia for a wide range of applications in life sciences, pharmaceutical, food and agricultural analysis, quality control and process analysis applications and 5 table content solutions.
Infrared and Raman spectra, as simple, fast, non-destructive and reliable techniques, are widely used in research and industry, from basic sample identification and quality control to advanced research.
The Brooke optics division uses Fourier transform and dispersed Raman measurement techniques in a wide range of laboratory and process spectrometer.
The products of the Brook optics division are supplemented by a range of sampling accessories and technologies, which include microanalysis and high
Throughput Screening helps users find the right solution to analyze their samples effectively.
Our customers in the brookcard group include pharmaceutical, biotechnology and diagnostics companies, contract research organizations, academic institutions, medical schools, non-profit orfor-
Profit forensics, agriculture, food and beverage safety, environmental and clinical microbiology laboratories, hospitals and government departments and institutions.
During 2018, we launched many new product solutions and additional workflows based on mass spectrometry, including the MALDI Biotyper \"Bologna\" workflow, timstofprotm
We also received a 80% interest in Hain LifescienceGmbH (\"Hain\")
And you can choose to get the remaining 20% after 2022.
Hain, an infectious disease expert, provides a wide range of molecular diagnostic solutions for the detection of microbial and viral pathogens and molecular antibiotic resistance tests.
The instruments of TheBruker CALID Group are based on the following technical platforms: alimmaldi-TOFx97Matrix-
Analytical Ionization Time by auxiliary laserof-
Flight Mass Spectrometry including tandem timeof-Flight system (MALDI-TOF/TOF); x95ESI-
Ionization Time of electric sprayof-
Flight spectra, including ESI-based tandem mass spectrometry systemsquadrupole-
Time of flight mass spectrometry (ESI-Q-q-TOF);
Magnetic resonance mass spectrometry, including a hybrid system with an aquadrupole front end (Q-q-MRMS);
Ion Trap Mass Spectrometry; x95GC-
Using the triple mass spectrometry systemquadrupoletime-of-
Flight Mass Spectrometry; x95LC-
Using the triple mass spectrometry systemquadrupoletime-
Flight Mass Spectrometry; x95FT-
Infrared spectrum; x95NIRx97Near-
Raman spectrum. MALDI-
TOFmass spectrometers uses the ionization process to analyze solid samples using a laser that combines high sample flux with a high quality range and sensitivity. Our MALDI-
The application of time-of-flight mass spectrometry in clinical diagnosis, environmental and classification studies, and food processing and quality control is particularly useful.
The specific applications include: Analysis of oligomer nucleotide and synthetic polymer;
Identification and quantification of proteins;
Peptide sequencing from scratch;
Determination of position
Translation modification of protein
Analysis of proteomics and protein function
Discovery and development of drugs;
And rapid detection of body fluids and tissue peptides or protein biomarkers.
MALDI mass spectrometry allows users to quickly and reliably classify and identify microorganisms with minimal sample preparation workload and lifecycle costs.
Our MALDI Biotyper solution serves the clinical microbial market and enables the identification, classification or cancellation of microorganisms such as bacteria, yeast and fungi.
TOFmass spectrometers analyze liquid samples using an electric spray ionization process.
This ionization process, which does not disintegrate molecules, allows for the rapid acquisition and analysis of data from large biological molecules. ESI-
Time-of-flight mass spectrometry is particularly useful for identification, protein analysis and functional complex analysis in proteomics and protein function;
Molecular Identification in analysis of metabolites, natural products and drug metabolites
Combined chemistry for high throughput screening
And rapid liquid chromatography mass spectrometry or liquid chromatography mass spectrometry (LC-MS)
In drug discovery and development.
MRMSsystems uses high
Field magnets provide the highest resolution, selectivity and mass accuracy currently achievable in mass spectrometry.
Our systems based on this technology don\'t usually take time.
Consumption separation technology in complex mixture analysis.
In addition, our system can perform fragmentation of molecular ions and perform accurate mass analysis of all fragments to determine the molecular structure.
The MRMS system is particularly useful for studying the structure and function of biological molecules, including proteins, DNA and natural products;
Complex Mixture analysis including body fluid or combination Library; high-
Proteomics and metabolic OMICSand top-
Before the analysis, no enzyme digestion of the protein is required to reduce the proteomics of intactproteins. We offer next-
A generation of hybrid MRMS systems that combine the conventional external four-stage bar mass selector and six-pole collision pools with high
Performance MRMS for further ion dissociation, top-
Next proteomics tools and super
High resolution detection.
ITMSsystems collects all ions at the same time, which improves sensitivity compared to the previous four-stage Rod mass spectrometer.
Ion trap mass spectrometry is particularly suitable for sequencing and identification based on peptide structure analysis, quantitative liquid chromatography mass spectrometry, combination library identification, and generally improving the speed and efficiency of drug discovery and development processes. GC-
MSsystems combines the features of gas chromatography and mass spectrometry to identify the different substances in the test sample.
These two components are used together, and when used separately, finer substance recognition is allowed than any system.
The result is a quantitative analysis of the composition and mass spectrum of each component. Our GC-
The MS system is equipped with a triple four-bar configuration and can be configured with multiple options to suit various applications. Our GC-
MS systems are used in food and product safety, forensics, clinical and toxicology testing, and environmental, pharmaceutical and chemical analysis. LC-
MSsystems combines the separation features of liquid chromatography with the molecular identification features of mass spectrometry for the separation, identification and quantitative testing of different substances in samples.
As a supplementary technique of GC-
Analysis of ms lc-for volatile compounds-
MS can be used to analyze a variety of non-
Volatile compounds in complex samples. Our LC-
In order to meet the specific needs of users, there are multiple configurations available for the MS system.
Although it is mainly used in life science applications, our lc-
MS systems are also used in food and product safety, forensics, clinical and toxicology testing, and environmental, pharmaceutical and chemical analysis. FT-
In the use of IRspectrometersand far-
Infrared region of the spectrum. Our FT-
Infrared systems are commonly used in a variety of quality control and material research applications.
NIRspectrometers take advantage of the near
Infrared region of the spectrum.
Our NIR instruments are mainly used for quality and process control applications in pharmaceutical, food and agricultural and chemical industries.
The pharmaceutical industry is a leading user of NIR instruments and applications include quality control, R & D and process analysis technologies.
The food and agriculture industry is the second largest user of NIR instruments and there is a growing demand for quality control of food, food and beverages.
The content table sramanspectroscopy provides information about molecular structure.
The mechanism of Raman scattering is different from infrared absorption, because the Raman spectrum and infrared spectrum provide complementary information.
Raman spectroscopy is useful for the identification of organic and inorganic compounds and functional groups.
It is a non-destructive technology that can be used for the analysis of liquids and solids.
Raman is ideal for use in the polymer and pharmaceutical industries, as well as applications in the metal, electronics and semiconductor industries.
This technology is also used in life sciences, forensics and artwork certification.
In addition, the Brook testing department provides a variety of portable Analytical and Bioanalytical testing systems and related products for CBRNE testing.
Our customers use these devices for nuclear, biological and chemical agent defense applications,-
Terrorism, law enforcement, process and facility monitoring.
Our CBRNE inspection products use many of the same technology platforms as our life sciences products, as well as other technologies including infrared brackets
Off detection and ion migration spectrum of handheld chemical detectors.
We also offer integrated, comprehensive inspection kits including our multiple inspection systems, consumables, training and simulators.
The Brook Nano group includes the Brook AXS, The Brook nano-surface, the Brook nano-analysis and the brook semiconductor division.
Brook AXSDivision advanced X-design, manufacturing and distribution-
Ray instruments using very short-wavelength radiation to determine matter and three features
Size structure of molecules.
This includes the X-of the product\'s tool portfolio-
X-ray fluorescence spectrum (XRF), X-
Ray diffraction (XRD)and X-
X-ray computed tomography (µCT)
And the spark emission spectrum system (S-OES)
Used to analyze the concentration of elements in metal samples.
The products of the BrukerNano surface division include atomic force microscope instruments (AFM).
This instrument uses nano-scale probes to provide atomic or near-atomic resolution of surface topography and mechanical, electrical, and chemical information.
In addition, the Brook nano-Surface division also provides advanced fluorescent optical microscope instruments for multiple fields.
Photon, multi-point scanning co-focus and highspeed 3D super-
Resolution research in life science applications.
Brook Nano Surface division also provides non-
Contact with nano-resolution terrain via white light interference and stylus contour.
Production and sales of electronic microscope analysis tools, including energy analysis tools, by TheBruker Nano Analysis Departmentdispersive X-
Ray Spectrometer (EDS)
Electron reverse scattering diffraction system (EBSD)
And ct accessories, as well as moving and benchestop micro X-
Ray fluorescence (µXRF)
Total reflection X-
Ray fluorescence meter (TXRF)
Handheld, portable and mobile X-
Ray fluorescence (HMP-XRF)
Manufacturers and markets X-
X-ray metrology and automatic AFM defects
Semiconductor process control testing equipment.
Our customers at Brook Nano group include academic institutions, government customers, nanotechnology companies, semiconductor companies, raw material manufacturers, industrial companies, biotechnology and pharmaceutical companies, and other businesses involved in material analysis.
In 2018, we launched several new products, including an innovative and customizable next-generation Plaid film, a film cleaning module for neuroscience, and the next generation.
We acquired Anasys Instruments.
Jpkinstrument entyal is a developer and manufacturer of nano infrared spectroscopy and thermal measuring instruments, the table contains on-site expertise
Cell Imaging, cell mechanics, adhesion and molecular force measurements, light capture, and biological stimulation-
Response to Bruker capabilities andAlicona imagingmbh, an optical-based provider of dimensional measurement products.
The system of TheBruker Nano Group is based on the following technical platform: polycrystal line X-
X-ray diffraction, usually called X-ray diffractionRay diffraction; x95XRFx97X-
Ray fluorescence, also called X-
Ray Spectra including handheld XRFsystems; x95SC-
Single crystal X
X-ray diffraction, usually called X-ray diffraction
Energy dispersion X-
Ray spectrum on electron microscope
Electron reverse scattering diffraction on electron microscopex95S-
Spark Emission Spectrum;
Combustion analysis of carbon, sulfur, oxygen, nitrogen and hydrogen solids;
Atomic force microscope;
Fluorescent optical microscope;
Stylus and optical metering;
Friction and mechanical testing systems for friction and wear analysis.
XRDsystems studies multi-crystal samples or films with single wavelength X-rays.
Atoms in multi-crystal samples are X-
The light produces a unique diffraction pattern recorded by the detector.
Computer software processes patterns and produces a variety of information, including stress, texture, qualitative and quantitative phase composition, crystal size, percentage of crystals and layer thickness, composition, defects and density of thin films and semiconductor materials.
Our X-ray diffraction system helps reduce the development cycle of new products in the catalyst, polymer, electronics, optical materials and semiconductor industries.
Customers can also use our X-ray analysis system academic and government research facilities, as well as a variety of other areas including forensics, art and archaeology.
XRFsystems determines the composition of the elements of the material and provides a comprehensive qualitative and quantitative analysis.
Ray on the sample, atomic absorption X-in the sample-ray energy.
Then the elements in the sample emit X-
Characteristic light of each element.
System acquisition X-
The data obtained by the software analysis to determine the existing elements.
Automation solutions for our products
Industrial users need automated, controlled production processes to reduce product and process costs, increase production and improve product quality.
Our X-ray products basically cover all the periodic tables and can analyze samples of solids, powders, or liquids. SC-
XRDsystems determine three-
The size structure of molecules in the chemical, mineral or biological substances analyzed. SC-
The X-ray diffraction system is able to determine the structure of small chemical molecules and large biological molecules. SC-
The beam harness on the solid crystal sample.
The atoms in the crystal sample disperse X-
The light produces an accurate diffraction pattern recorded by an electronic detector.
The software then rebuilds the structural model and provides a unique arrangement of the atoms in the sample.
Information about the precise arrangement of atoms in the sample is a key part of molecular analysis and can provide insight into various fields, including how proteins interact or interact with the second molecule. Our SC-
In the life sciences industry, academic research and a variety of other applications, X-ray diffraction systems are designed for use.
9 Content table X-ctis
3D ray imaging is used in hospital CT scans in the same way, but in a small range the resolution is greatly improved.
The 3D microscope allows the user to perform imaging of the internal structure of a non-object
Destructive on a very fine scale.
Brook ct is available in Europe-to-
Using desktop instruments, these instruments generate 3D images of sample form and internal microstructure with resolution up to sub-resolutionmicron level.
Our ct systems are used in many applications in the material research and life sciences industries.
EDSsystems irradiated X-when the atoms of different chemical elements were exposed to high-energy electron beams produced by the microscope-
Ray of different characteristic energy
The evaluation of the energy spectra collected by our spectrometer allows the determination of qualitative and quantitative chemical sample components at the current beam position.
The EDS system allows simultaneous analysis of all elements in the periodic table starting with atomic number 4 (beryllium).
Our EDS systems are used in a variety of applications, including nanotechnology and advanced material research, as well as material analysis and quality control.
Customers of EDS systems include industrial customers, academia and government research institutions.
EBSDsystems is used for quantitative microstructure analysis of crystal samples in electron microscopy.
The selected beam of the microscope strikes the tilted sample and forms a diffraction electron pattern on the fluorescent screen.
This pattern is characterized by the crystal structure and orientation of the sample area that produces this pattern.
It provides an absolute crystal orientation with a subcrystal orientation
EBSD can be used to characterize the crystal orientation, texture, stress, strain, and grain size of the material.
EBSD also allows the identification of crystal phases and their distribution and is applied to many industries such as metal processing, aerospace, automotive, micro-electronics and Earth Science. S-
OESinstruments is used to analyze metals. S-
Oe covers a wide range of applications from pure metal trace analysis to metal analysis of high alloy grades and allows for simultaneous analysis of a range of related elements. S-
These instruments transmit a spark to a sample that burns the surface of the sample, causing the atom to jump to a higher orbit.
Our detectors quantify the light emitted by these atoms and help our customers determine the elemental composition of the material.
This technology is widely used in the production control laboratory of Foundry and steel mill.
The CS/ONHcarrier gas system combines furnace and infrared or thermal conductivity detection for the analysis of inorganic materials used for the determination of carbon, sulfur, nitrogen, oxygen and hydrogen.
Combustion and inert gas fusion analyzers are used in the fields of metal production and processing, chemistry, ceramics and cement, coal processing, refining and semiconductors.
AFMsystems provides atoms or near
Atomic Resolution of surface topography of materials using nanotechnology
Scale probe in light contact with the sample under investigation.
In addition to presenting surface images, AFM can also provide a quantitative nano-scale
Dimensional measurements of characteristic dimensions, material properties, electronic information, chemical properties, and other sample properties.
Our AFM systems are used in the development and manufacture of academic and government materials as well as applications in biological research and semiconductors, data storage hard drives, LED, batteries, solar cells, polymers, and pharmaceutical products.
FMproducts uses a fluorescence microscope to determine the structure and composition of life science samples.
We have two products.
Photon microscopy, multi-point scanning co-focal microscopy, laser lighting sources, light activation, light stimulation and light ablation accessories, and synchronous and analytical software. Two-
Photon microscopy can be used in the field of tissue and cell imaging and is widely used in Neurology.
The multi-point scanning co-focus system allows real-time cell imaging by quickly obtaining images for structure and component analysis.
We also offer super
Resolution and single
It can break the optical diffraction limit by an order of magnitude of molecular positioning microscope products.
The 10 ContentsSOMsystems table provides atoms or near-
Atomic 2D and 3D surface resolution using white light interference, co-focal optics, and stylus contour methods.
SOM profile from low range
Cost manual tools for single measurement, advanced, highly automated systems for production line equality assurance and quality control applications where a combination of throughput, repeatability and repeatability is critical
SOM profiler supports a range of applications in automotive, plastic surgery, ophthalmology, research on highlighted LEDs, semiconductors, product development, friction, quality control, and fault analysis related to materials and processing, data Storage, Optics and other markets.
TMTsystems provides a platform for a wide spectrum of materials for a variety of common mechanical, friction, durability, scratch and indentation tests.
Friction systems are used in academic research on basic material properties and industrial applications in semiconductor, aerospace, petroleum, automotive and other industries.
Optimal segmented optimum design, manufacture and distribution of superconductive materials for magnetic resonance imaging, nuclear magnetic resonance, polymorph studies and other applications, mainly metal low temperature magnets.
BEST also develops, manufactures and sells ceramics, second generation high temperature super capacitors for energy technology and magnet research applications.
In addition, BEST is mainly based on metal low-temperature super conductors applied in \"big science\" research, including RF accelerator cavities and modules, developing, manufacturing and selling complex equipment and complex tools, power coupler and linear accelerator.
It\'s also the best manufacturer and sellsnon-
Mainly for customers engaged in material research and \"big science\" research projects, such as synchronous accelerators and beam line instruments.
Sales and marketing we maintain direct sales force in North America, Europe, Russia, China, Japan and elsewhere in the Asia Pacific region.
We use indirect sales channels to reach customers.
We have a wide range of international distributors, independent sales reps and various other reps in parts of Asia, Latin America, Africa, Middle East and Eastern Europe.
These entities have expanded our direct sales team and provided coverage in areas where we do not have direct sales personnel.
In addition, we adopt the distribution business model to establish strategic distribution alliances with other companies to meet specific market segments.
The sales cycle of our products depends on the size and complexity of the system and the budget cycle of the customer.
Our sales cycle is usually three to twenty.
4 months of study and high school
Final research products for industrial products and two weeks to six months.
The sales cycle of our low-temperature superconductive materials is usually 4 to 12 months, some of which are high-powered.
Final material for more than a year.
Our high sales
Terminal NMR and hypermagnetic devices usually take more than one year, while some large, complex contracts take more than two years to complete. Wehave well-
Equipped application and demonstration facilities and qualified application personnel who assist customers in specific application areas and provide product demonstrations.
We maintain our main demonstration facilities in our production facilities and other major market locations.
In terms of business seasonality, we have a higher level of revenue in the fourth quarter and a lower level of revenue in the first quarter, which we believe is affected by the customer\'s budget cycle.
We have a broad and diverse customer base and we do not rely on any one customer.
As of December 31, 2018 or 10%, none of the clients had earned more than 10% of their income in the last three fiscal years and accounts receivable exceeded 2017.
Competing for our existing products and solutions, and any products and solutions we will develop in the future, can compete in multiple competitive markets.
In addition, there is a trend of integration in our industry, and many of our competitors have far more financial, technical and marketing resources than we do.
Our competitors may successfully develop and deliver products that make our products or products of strategic partners obsolete or uncompetitive.
Our competitors may also have a cost and price advantage based on monetary value compared to the USS. Dollar or Euro.
In addition, many competitors have more experience in the life sciences, chemistry and materials market.
Our ability to compete successfully will depend on our ability to develop proprietary products that enter our target market in a timely manner that are technically superior and/or cheaper, or more cost-effective, than our competitors sell products.
Current competitors or other companies may own or develop technologies and products that are more effective than us.
Our technology and products may become obsolete or uneconomical because of technological advances or completely different methods developed by one or more of our competitors.
We also compete with companies that provide analytical or automated tools based on technologies other than those we offer.
These technologies may be more successful in meeting the market needs of our products and solutions.
In addition, other companies may choose to enter our field in the future.
We believe that the main competitive factor in our market is technology.
Based on application expertise, product specifications, functionality, reliability, marketing expertise, distribution capabilities, proprietary patent portfolio and cost-effectiveness.
BSI SegmentBruker BioSpin competes with companies that offer magnetic resonance spectrometer, mainly JEOL and Oxford Instruments.
In the field of pre-clinical imaging, Bruker BioSpin competes with Perkin Elmer, Mediso, Trifoil, MR Solutions, etc.
Bruker CALID competes with a variety of companies that offer mass spectrometry-based systems.
Bruker CALID\'s competitors in the life sciences market, chemical and application markets include Danaher, Agilent, GE-
Healthcare, Waters, hot Fisher Science, Shimizu, Hitachi and JEOL.
In the microbial market, we compete with biotech companies.
Bruker CALID\'s CBRNE detection customers are very fragmented and we compete with many companies in this area, the most important of which is Smiths detection.
Bruker CALID also competes with a variety of companies that offer molecular spectrum-based systems, including Semer Fisher Science, PerkinElmer, Agilent, Foss, ABB
In addition, there are several smaller companies specializing in various markets.
Bruker Nano competes with companies that offer analytics X
Ray solutions, oe systems, AFM and SOM systems, and optical fluorescence systems, primarily Rigaku, Oxford Instruments, Agilent, thermal Fisher Science, Spectro of Ametek, and Zeiss\'s Leica business with Danaher.
The best market segment can best compete with Luvata, a Western superconductive technology company. ,Ltd. (WST), and JastecCo. ,Ltd.
In low temperature superconductive materials
In addition, with the superpower Fujikura (
An ancient river Company)
, Superconductive nesiesinc. and SuNamCo. ,Ltd.
Table 12 Market situation of the second generation high temperature magnet materials.
In the development and supply of accelerator cavities, BEST on, Mitsubishi Motors and AES further compete with Thales, Toshiba and CPI International to develop and supply RF coupler, develop and supply the superconductive accelerator module with Mitsubishi Heavy industry and provide AES and Thales for the electronic linear accelerator.
Several of our manufacturing plants manufactured and supplied have passed the certification of ISO9001: 2008 and international quality standard iso13135.
We produce and test our magnetic resonance products at our factory in Faellanden, Switzerland;
Fort wensburg, France;
And Germany\'s carlsruer.
We produce and test our pre-clinical imaging products at our factory in Ettlingen, Germany;
Fort wensburg, France;
And Faellanden in Switzerland.
We produce and test our mass spectrometry products, including CBRNE detection products, at our factories in Bremen, Germany and Leipzig, Germany.
We mainly produce and test our molecular spectrum products at our factory in Ettlingen, Germany.
We produce and test our products.
We offer ray, oe and AFM products at our factory in Carlsruhe, Germany;
American Wisconsin MadisonS. A. ;
California Santa Barbara AmericanS. A. ;
Washington, United States of AmericaS. A. ;
Migdar Haemek of Israel
We produce and test most of our energy and low temperature products at our factory in Hanau, Germany;
Borscher Gladbach, Germany
Perth, Scotland and Carteret, New JerseyS. A.
Our manufacturing process in factories in Europe, Israel and California, USAS. A.
Includes all stages of manufacturing such as processing, manufacturing, sub-components, system assembly, and final testing.
Our other facilities are mainly high.
System integration and final testing.
We usually have-
Ensure critical capabilities and outsourcing of third-party manufacturers
We buy materials and components from a variety of suppliers that are either standard products or manufactured to our specifications.
We get some components contained in the product from a limited supplier group or a single supplier
Source supplier of charge coupling equipment area detector, X-and other items
Optical tube, robot, infrared optics, etc.
BEST has signed a continuous cooperation and joint technology development agreement with Allegheny Technologies to advance the national-of-the-art niobium-
Including MRI magnets for the medical industry, as well as pre-clinical MRI magnets for life --
Science tools industry
R & D we invest a lot of money and resources for internal and cooperative R & D projects in order to provide innovative products and solutions to our customers.
We mainly conduct research to improve system performance and reliability of existing products and develop revolutionary new products and solutions.
Our research and development work is carried out for the relevant products of each operation department, and is also carried out in cooperation with other companies in the fields of micro-fluid, automation and workflow management software.
We have been recipients of grants from the governments of Germany and the United States for various early-related projects
Stage R & D.
We usually keep at least
We have exclusive rights to any project or enhancements developed under these authorizations.
The government of Germany requested that, in order to retain our right to technology, the technology we use and market develop is lower than the grant.
We have also accepted a number of sponsored research contracts from private sources.
The research and development carried out by the BSI division in the German division is mainly carried out in our factories in Bremen, ertringen and karsruea, Germany;
Fort wensburg, France;
The table that will be taken is ContentsBillerica, Massachusetts, U. S. A. ;
American Wisconsin MadisonS. A. ;
San Jose and Santa Barbara, CaliforniaS. A.
TheBruker BioSpin group in core magnetic resonance technology and single-
Multimodal imaging techniques and capabilities including NMR, EPR, MRI, MPI, PET, and CT.
Recent projects include the development of solid state dynamic nuclear polarization technology, an ongoing development that can improve the sensitivity of NMR and perform high field emission using dedicated refrigerant-free magnets, high field magnet technology for pre-clinical MRI, basic NMR studies and biological studies with four-level tuned frozen probes, and MPIimaging for pre-clinical applications.
TheBruker CALID Group maintains technical capabilities in core mass spectrometry technologies and capabilities, including: MALDI, ESI and EI/CI ion sources, flight time/flight time, ion level 4 bar and IMS analyzer and bioinformatics.
Recent projects include innovative timsTOF mass spectrometer for the separation and analysis of unresolved compounds and conformations.
TheBruker CALID Group also maintains technical capabilities in terms of core vibration spectrum technology and capabilities, including FT-
IR, NIR and Raman spectra.
TheBruker Nano group in core X-
Ray technology and capabilities, including detectors for X-ray detectionray and X-
Generation and focusing of X-ray sources and optics
Ray, robot and sample processing equipment holding and manipulating experimental materials, and software that generates structural data.
Recent projects include a fluorescent microscope, at the same time, full-scale
Optical stimulation and imaging platforms for research in optical genetics neuroscience, as well as driving brain research and high
Study on distinguishing living cells
Bruker Nano group is also competitive in AFM technology, including
Position and motion control, and sub-
Piconewton force control.
Bruker Nano Group technology also includes a microscope based on 3D optical inference, stylus contouring, friction testing, Nano
Double dent of optical fluorescence
Optical microscope, multi-point scanning microscope and highSpeed, 3D Super
Resolution flowering microscope.
Recent innovations include an Elemental Analyzer System for advanced applications and research
An optical stimulation and imaging platform for neuroscience applications.
The best market segments are studied and developed in the best market segments mainly in our locations in Hanau, Germany, belghesh Gladbach and alzeno, Germany, and catteret, New Jersey, USAS. A.
Maintain the best technical capability in the production and development of low temperature and high temperature conductive materials and devices. BEST and CERN(
European Organization for Nuclear Research, Geneva, Switzerland)
There is an ongoing research and development agreement to advance the latest technology with nb
Tin-based magnets for particle accelerators and other large scientific magnet systems.
Intellectual property your intellectual property includes patents, copyrights, trade secrets, intellectual property
How and trademark.
Protecting our intellectual property rights is a strategic priority for our business, because the time and cost of bringing new products through the development process and the market is very long.
We have a large portfolio of patents and we intend to file additional patent applications as appropriate.
We believe that the patent portfolio that we have and are licensed gives us a competitive advantage.
This portfolio allows us to maintain access to some of the key technologies.
We license the patent rights we have in due course.
If necessary, we intend to enforce our patent right against the infringer.
The patent status of life science tools companies involves complex legal and factual issues.
Therefore, we cannot predict the enforceability of our patents with certainty.
In addition, 14 catalogues indicate that patents exist in certain countries from time to time and, if they are valid, may compromise our ability to produce and sell products in those countries.
We also rely on trade secrets.
How trademarks, copyright protection and licensing develop and maintain our competitive position.
We usually ask our employees, consultants, and other scientific consultants to perform confidential agreements.
These agreements provide that all confidential information known in the course of the relationship with us will be kept confidential and used only for our benefit.
In addition, these agreements provide that we have all the inventions that arise in the course of the relationship.
We are a party to various government contracts.
According to some of these government contracts, the government may obtain a license or similar right for intellectual property rights developed under the contract.
However, according to the government contract we sign, we usually receive at least
The exclusive right of any product or technology we develop.
Even though we do business with different government agencies, we don\'t think that the scale of a government contract is so large, to the extent that renegotiating profits or terminating contracts or subcontracts at the time of government elections can have a significant adverse effect on our financial results.
We must comply with federal, state and local environmental protection regulations.
We do not expect this compliance to have a significant impact on our capital expenditure, revenue or competitive position.
Priorto, our Bruker AXS subsidiary, launched a product in the United States and sent a notice to the United StatesS.
The Food and Drug Administration (FDA) provides identification information and operational features of the product in the form of a radiation safety initial product abbreviation report.
If the FDA finds that the report is complete, it will provide approval in the form of a so-called join number.
Bruker AXS may not sell the product until the registration number is received.
In addition, Bruker AXS submitted an annual report to the FDA, which includes the radiation safety history of all products it sells in the United States.
Bruker AXS must report to the FDA the incident of accidental exposure to radiation due to the manufacture, testing or use of any of its products.
Bruker AXS also reported on the installation of its products to the national government regulator responsible for the regulation of radiation launch devices.
For ingervice sales, Bruker AXS registered each system with the local authorities.
In some countries of the Bruker AXS sales system, Bruker AXS uses the licenses we have obtained from the German federal authorities to help it obtain licenses from the countries where sales occur.
OurBruker AXS subsidiaries have low
A horizontal radiation material permit issued by the local radiation safety agency Gewerbeaufsichtsamt Karlsruhe for its facilities in Karlsruhe, Germany;
Facilities of the local radiation safety administration in Kanagawa Prefecture in Yokohama, Japan, as well as facilities in other countries where products are sold.
Our subsidiary, BrukerDaltonics, has a low
Horizontal radiation permits for facilities located in Bianca, Massachusetts and Leipzig, Germany. The U. S.
The Nuclear Regulatory Commission also provides for exposure of our employees to radiation.
Some of our clinical products are regulated in the United States by similar regulatory authorities in the FDA and other countries that sell such products.
For example, our MALDI Biotyper CA system is subject to FDA and our IVD-
CE-certified MALDI BioTyper system is regulated in the EU in accordance with the provisions of the direcc98/79/EC.
These and similar local regulations in other parts of the world govern a variety of products.
15 forms for content sales and distribution from quality management, design and development to labeling, manufacturing, promotion and other related activities.
As a result, we are continuously investing in our manufacturing infrastructure to obtain and maintain the certification required at the relevant regulatory licensing level.
Liquidity needs do not provide customers with credit terms that have a significant adverse impact on our liquidity.
In the transfer of control, we receive revenue from the sales of the system, and the amount reflects the consideration we expect to get.
Control transfers usually occur at the time of shipment, or for certain systems, based on the customer\'s acceptance of the system after delivery and installation of the customer\'s facility.
For systems including customers
Specific acceptance criteria, we need to evaluate when it is possible to demonstrate that the acceptance criteria have been met, which is usually done after the success of the factory acceptance test or the success of the customer acceptance and installation evidence.
Systems that have been shipped to the customer but have not yet been accepted by the customer are included as finished products in-transit.
-Finished productThe transit fee is $38.
$3 million and $41.
4 million atDecember31, 2018 and 2017, respectively.
We also have
Equipped application and demonstration facilities and qualified application personnel who assist customers in specific application areas and provide product demonstrations.
We hold a total of $67.
$9 million and $54.
The demonstration stocks in December 31, 2018 and 5 million were 2017 respectively.
The backlog consists of non-placed fixed orders
Cancelable purchase orders received from customers.
The total system backlog as at December 31, 2018 and 2017 was approximately $1. 05 billion and $1. 01 billion respectively.
We expect that as of December 31, 2018, approximately 84% of the backlog will be filled in 2019.
We usually experience revenue changes and fluctuations in the first three quarters of this year, and our fourth quarter revenue has historically been stronger than the rest of this year.
Therefore, the backlog of any specific date may indicate our shortage
Long-term revenue performance, but not necessarily a reliable indicator of long-term income
Long-term revenue performance.
We have about 2017 and 6,870 employees in December 31, 2018 and 6,200
They are time employees around the world.
As of December 31, 2018, approximately 1,095 and 1,085 of these employees were located in the United States and 2017 respectively.
Our employees in the United States have not joined the Union and have not joined any labor organization.
Employees based outside the United States are mainly located in Europe, and the workers\' committees or unions are mainly located in Germany and France.
Several of our international subsidiaries are party to the contract with the Union and the workers\' committee.
We believe we have a good relationship with our staff and the workers Committee.
As of December 31, 2018, we have about 3,290 employees in production and distribution, 1,700 employees in sales and marketing, 1,135 employees in R & D, and the remaining employees are general and administrative
As of December 31, 2017, we have about 3,035 employees in production and distribution, 1,482 employees in sales and marketing, 1,000 employees in R & D, and the rest are general and administrative
Available information we are subject to the information requirements of the Securities Trading Act of 1934 (\"Exchange Act\").
Therefore, we submit periodic reports, agency statements and other information to the Securities and Exchange Commission (\"SEC\").
Such reports, proxy statements and other information are available on the SEC website (
The content source website table is located at atwww. bruker. com.
We provide our annual report on Form10 free of charge through this website
Quarterly Report on Form10
Q: Latest report on Form8
K, and amendments to reports submitted or provided to SEC under section s13 (a)or 15(d)
After the electronic submission to or provided to the SEC, it is submitted as soon as reasonably practicable.
The content of our website is not included in this report.
Item 1 ARISK factors the following risk factors shall be considered in conjunction with other information contained in this Annual Report on form 10K.
This report may include
Forward-looking statements involving risks and uncertainties.
In addition to these risk factors discussed elsewhere in this report, we have identified the following risk factors that may affect our actual results and lead to significant differences between actual results and forward results
Look at the report.
When we exchange the foreign exchange obtained from international sales into US currency, we may lose moneyS. Dollars.
A large part of our business is conducted in currencies other than the United States. S.
US dollar, our reporting currency.
Therefore, currency fluctuations between the United StatesS.